Venlafaxine
Venlafaxine is an antidepressant-anxiolytic better known by its trade name, Effexor ® (now Wyeth).
Venlafaxine hydrochloride is one of three SNRIs (reuptake inhibitors of serotonin and norepinephrine). Other SNRIs are known to Ixel ®, its molecule is milnacipran and Cymbalta ®, its molecule is duloxetine.
Venlafaxine is available in pharmacies in capsule 37.5 mg, 75 mg and 150 mg per dose for 24 hours only on prescription.
Pharmacokinetics
Persons with the allele (T, T) of rs2032583 gene ABCB1 SNPs are 7 times less likely to respond to treatment with Venlafaxine. This genetic variant is present in two thirds of people of European origin and up to 90% of Asians.
It is also important to note that poor metabolizers of CYP2D6 have a risk of overdose and therefore feel much more side effects, even at low doses.
Indications
Venlafaxine is used in severe depression and panic disorder with or without agoraphobia.
Efficiency
In panic disorder, Upper French health authority estimates in its opinion in October 2008 that venlafaxine "does not improve the medical service delivered over other available drugs in this indication. The studies do not prove efficacy of the molecule before 12 weeks of treatment compared with placebo. They also show that relapse of panic disorder were less numerous after six months of treatment in responders to venlafaxine.
Dosage
Follow the recommendations of their doctor and follow the dosage instructions on the label. As this is a form of incentive, it is best taken in the morning, with or without food. To avoid side effects, it is recommended to use a progressive mix for the first 10 days. At the end of use, do the reverse process a few weeks (weaning). Avoid alcohol or drink alcohol.
Common side effects
The reactions to venlafaxine may differ from one person to another. In cases of adverse reactions, consult a doctor or a pharmacist.
* Disruption of sleep
* Nausea (21-35%)
* Headache (34%)
* Apathy
* Constipation
* Colon Irritable
* Dizziness (11-20%)
* Fatigue
* Insomnia (15-23%)
* Dizziness
* Dry mouth (12-16%)
* Impotence
* Decreased libido (14-34%)
* Excessive sweating (10-14%)
* Tinnitus
* Orthostatic hypotension
* Vivid dreams / abnormal (3-7%)
* Shares impulsive
* Increased blood pressure
* Loss of appetite (8-20%)
* Feelings of shock ( "Brain zaps" in English)
* Increased anxiety in early treatment
* Akathisia (Agitation) (3-4%)
* Memory loss
Less common side effects
* Cardiac Arrhythmia
* Increased cholesterol
* Flatulence or upset stomach
* Abnormal vision
* Panic attacks
* Depression
* Suicidal thoughts
* Confusion
* Neuroleptic malignant syndrome
* Tremor
* Drowsiness
* Allergic skin reactions
* External bleeding
* Damage to the bone marrow (thrombocytopenia, agranulocytosis)
* Hepatitis
* Pancreatitis
* Convulsions
* Tardive Dyskinesia
* Difficulty swallowing
* Psycho
* Hair loss
Hostility *
* Activation of mania / hypomania.
* Weight Loss (problematic when treating patients with anorexia nervosa)
* Weight gain (effect uncertain, but problematic when treating people with dysmorphic disorder).
* Ideas deadly
* Aggressiveness
* Depersonalization
* Visual Hallucinations
* Swollen gums and / or bleeding
* Frequent urination
* Vomiting
Read also Antidepressant Medication
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